Simple Buffalo Chicken, Sweet Potato & Broccoli Casserole

If you love bold buffalo flavor but also want something nourishing and easy, this Buffalo Chicken, Sweet Potato & Broccoli Casserole is about to become a new favorite. It is spicy, cozy, and packed with protein and veggies – all baked together in one pan for minimal cleanup.
Tender roasted sweet potatoes form the perfect base, then juicy buffalo chicken and crisp broccoli get tossed in, finished with melty cheddar and your favorite toppings. It’s comforting without feeling heavy and comes together with simple ingredients, making it perfect for busy weeknights or make-ahead meal prep. Bonus: you can customize every serving with ranch, avocado, or crunchy veggies depending on your mood.
How This Recipe Can Support Inflammation & Endometriosis
This casserole brings together several ingredients that can be supportive for inflammation-conscious eating:
- Sweet potatoes are rich in fiber and antioxidants, helping support gut health and stable blood sugar, which are both important when managing inflammation.
- Broccoli is a cruciferous vegetable that supports natural detox pathways and hormone balance, which can be especially helpful for those navigating endometriosis symptoms.
- Chicken thighs provide high-quality protein to support muscle repair, satiety, and steady energy throughout the day.
- Avocado oil offers healthy fats that may help reduce inflammatory responses and support overall hormone health.
While buffalo sauce brings the heat, pairing it with grounding ingredients like sweet potatoes and optional cooling toppings (ranch, avocado, celery) helps create a balanced dish that feels satisfying without being overwhelming.
Why You Will Love This Recipe
- One-pan dinner = easy cleanup
- Packed with protein and colorful veggies
- Big buffalo flavor with cozy comfort vibes
- Completely customizable with your favorite toppings
- Great for meal prep
- Naturally gluten-free and easy to adapt
Whether you keep it classic with ranch and celery or load it up with avocado and fresh herbs, this casserole fits right into busy weeks, cozy nights, and everything in between.

Buffalo Chicken, Sweet Potato & Broccoli Casserole
Ingredients
Method
- Preheat oven to 425°F and lightly grease a 9×13 casserole dish.
- Wash and cube the sweet potatoes and chicken. Cut broccoli into bite-size pieces. Season chicken lightly with salt and pepper and set aside (you can refrigerate while prepping everything else).
- In a small bowl, whisk together buffalo sauce, avocado oil, salt, pepper, garlic powder, and onion powder.
- Add sweet potatoes to the casserole dish. Pour half of the sauce over them and toss until evenly coated.
- Bake uncovered for 30 minutes, stirring halfway through for even browning.
- Remove dish from oven. Add chicken and broccoli, then pour remaining sauce over everything. Toss gently to combine.
- Return to oven and bake for 25 minutes, or until chicken is cooked through and sweet potatoes are fork-tender.
- Sprinkle cheddar evenly over the top and bake an additional 3–5 minutes, just until melted.
- Drizzle with dressing and add toppings, if desired. Serve warm.
